HotPatch Web Gateway
Statistical Analysis of Unusual Patches on Protein Surfaces
HotPatch finds unusual patches on the surface of proteins, and computes just how unusual they are (patch rareness), and how likely each patch is to be of functional importance (functional confidence (FC).) The statistical analysis is done by comparing your protein's surface against the surfaces of a large set of proteins whose functional sites are known.
We provide the software here that ran this server online in the past. You are welcome to download these programs and run them on a Linux computer freely. Each program comes with instructions on how to use them.Tarred Gzipped file here
We have disabled the online version due to security holes in the c++ code, and apache access issues.
If you have any comments or questions, please contact holton at mbi dot ucla dot edu